Dept. of Dermatology - University of Iowa College of Medicine

Dermatology Differential Diagnosis by Morphology

Macular Lesions
Brown	Grey Slate Blue	Black
White	Pink - Red	Yellow
Scale

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Brown Macular Lesions

Ephilides
Neurofibromatosis - #2 and #3
Albright's disease
Peutz Jeghers syndrome
Xeroderm pigmentosum
Acropigmentation
Central lentigines
Seborrheic keratosis
Neurocutaneous melanosis
Nieman-Pick disease
Melasma (Chloasma)
Kwashiokor
Photochemical reactions
Berlock dermatitis
Ultraviolet light (sun tan)
Thermal radiation - Erythema ab igne -#1 and #2
Becker's nevus
Hemochromotosis

Trauma
Post-inflammatory hyperpigmentation
Malignant melanoma
Lentigo melanoma
Mastocytosis (urticaria pigmentosa)
Encephalitis (chronic)
Cronkhite - Canada syndrome
Tatoo
Reticular acropigmentation of Kitamura
Dermatopathia pigmentosa reticularis
Fanconi's syndrome
Riehl's melanosis
Periorbital melanosis
Franceschetti - Jadassohn syndrome
Gaucher's disease
Dyskeratosis congenita
Addison's disease

Grey Slate Blue Macular Lesions

Oculodermal melanocytosis (Nevus of Ota)
Dermal melanocytosis (Mongolian spot)
Blue melanocytic nevus
Incontinentia pigmenti
Franceschetti - Jadassohn syndrome
Hemochromotosis
Chronic nutritional insufficiency
Fixed drug eruption
Pinta
Erythema dyschromicum perstans
Malignant melanoma
Tatoo
Maculae cerulae
Ochronosis
Metastatic melanoma and melanogenuria

Black Macular Lesions

Melanocytic nevus
Malignant melanoma
Ecchymosis (blue-black)

White and Hypomelanotic Macular Lesions

Vitiligo
Albinism
Piebaldism
Vogt-Koyanagi-Harada syndrome
Tuberous sclerosis
Waardenburg's syndrome
Hyperthyroidism
Hypoparathyroidism
Addison's disease
Hypopituitarism
Pernicious anemia
Halo nevus (Leukoderma acquisitum centrifugum - Hyde and Sutton)
Nevus depigmentosus
Leprosy - tuberculoid
Pityriasis alba
Chediak-Higashi syndrome
Post-inflammatory depigmentation
Phenylketonuria (pigment dilution)
Alezzandrini's sundrome
Idiopathic guttate hypomelanosis
Syphilitic leukoderma (L2)
Scleroderma / morphea - #2

Pink - Red Macular Lesions

Exanthems
Drug eruptions
Telangiectasia
Nevus flammeus (Port wine stain - salmon patch)

Yellow Macular Lesions

Jaundice
Xanthomata (plantar - plantar)
Xanthelasma (sometimes paplable)
Carotenemia
Pseudoxanthoma elasticum
Necrobiosis lipoidica diabeticorum - #2#3
Amyloidosis (primary)
Fordyce condition
Solar elastosis

Macules with Scale

Tinea versicolor
Seborrheic keratosis
Stucco keratosis
Pityriasis alba

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June, 1996

Dept. of Dermatology / University of Iowa /

Last updated March 13, 1997