Dept. of Dermatology - University of Iowa College of Medicine

M. S. Stone and T. L. Ray

Pleomorphism

The variation in the appearance of the nuclei of the same cell type. If pronounced and associated with large, irregular, hyperchromatic nuclei it is termed anaplasia and is often an indication of malignancy.
Example of pleomorphism in Superficial Spreading Malignant Melanoma.

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September, 1995

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